Analysis of molecular mechanism and physiological functions of the stress-responsive nucleocytoplasmic transport mediated by Hikeshi

2016 Fiscal Year Final Research Report

• Project/Area Number: 26440109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Kose Shingo 国立研究開発法人理化学研究所, 今本細胞核機能研究室, 専任研究員 (90333278)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 核-細胞質間輸送 / 熱ストレス / 分子シャペロン / Hikeshi

Outline of Final Research Achievements

Nuclear import of molecular chaperone HSP70 under heat-stress conditions is mediated by a nucleocytoplasmic transport carrier, Hikeshi. This study revealed that V54L point-mutation in Hikeshi gene is associated with a severe hereditary disease. These results suggest that Hikeshi is likely to have important role(s) not only under heat-stress conditions, but also in various cellular situations. Further, we reported the crystal structure of Hikeshi. These studies provided insights into new mechanism and functions of the Hikeshi-mediated transport.

Free Research Field

細胞生物学