2016 Fiscal Year Final Research Report
Analysis of molecular mechanism and physiological functions of the stress-responsive nucleocytoplasmic transport mediated by Hikeshi
Project/Area Number |
26440109
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
|
Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Kose Shingo 国立研究開発法人理化学研究所, 今本細胞核機能研究室, 専任研究員 (90333278)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 核-細胞質間輸送 / 熱ストレス / 分子シャペロン / Hikeshi |
Outline of Final Research Achievements |
Nuclear import of molecular chaperone HSP70 under heat-stress conditions is mediated by a nucleocytoplasmic transport carrier, Hikeshi. This study revealed that V54L point-mutation in Hikeshi gene is associated with a severe hereditary disease. These results suggest that Hikeshi is likely to have important role(s) not only under heat-stress conditions, but also in various cellular situations. Further, we reported the crystal structure of Hikeshi. These studies provided insights into new mechanism and functions of the Hikeshi-mediated transport.
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Free Research Field |
細胞生物学
|