2017 Fiscal Year Final Research Report
Analysis of Hedgehog signaling-mediated regulation of cell dynamics in the early embryo
Project/Area Number |
26440130
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Developmental biology
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Research Institution | Osaka Medical College (2015-2017) JT Biohistory Research Hall (2014) |
Principal Investigator |
Akiyama-Oda Yasuko (秋山康子) 大阪医科大学, 医学部, 非常勤講師 (80426650)
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Research Collaborator |
ODA Hiroki 株式会社生命誌研究館, 主任研究員 (50396222)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Keywords | ゲノム / 遺伝子発現 / 初期発生 / ヘッジホッグシグナル |
Outline of Final Research Achievements |
Hedgehog signaling has an important role in various developmental events. In the embryo of the spider Parasteatoda tepidariorum, Hedgehog signaling regulates early developmental events, such as anterior-posterior patterning, orientation of the dorsal-ventral axis, and morphogenesis. In this study, we performed genome-wide searches to identify target genes of Hedgehog signaling. We combined RNAi and RNA-seq techniques and identified many target genes that show region-specific expression in the early embryo. One of the identified genes, msh is found to be involved in segmentation and formation of the germ band.
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Free Research Field |
発生生物学
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