2017 Fiscal Year Final Research Report
Rational design of DyP type peroxidase based on the topology
| Project/Area Number |
26450132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Japan Women's University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUGE Hideaki 京都産業大学, 総合生命科学部, 教授 (40299342)
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| Research Collaborator |
YOSHIDA Toru 京都産業大学, 総合生命科学部, 研究助教 (30724546)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | DyP / DyP型ペルオキシダーゼ / 分子進化 / 収束進化 / タンパク質工学 |
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| Outline of Final Research Achievements |
DyP-type peroxidase is a novel peroxidase family, which was defined in 2007. Therefore, we had little known its physiological function and structure. In this study, we tried to solve the relationship between its structure and function. Interestingly, DyP-type peroxidase family has been found to be devided to 3 classes, that is classes P, I and V based on strucutral based homology alignment. Moreover, each class must be evolved independently from different origin. It suggests that some of proteins as well as DyP-type peroxidase family also do convergent evolution as some organisms.
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| Free Research Field |
分子進化
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