2016 Fiscal Year Final Research Report
Elucidation of epigenetic mechanisms underlying the intestinal symbiosis for improvement of intestinal environments by foods
| Project/Area Number |
26450165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 食品機能 / 腸管上皮 / 腸内細菌 |
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| Outline of Final Research Achievements |
To elucidate the molecular mechanisms underlying the intestinal symbiosis, epigenetic regulation of intestinal epithelial function by gut microbiota was analyzed. It was shown that gut microbiota-dependent miRNA in intestinal epithelial cells regulates intestinal epithelial permeability. It was also shown that another miRNA abundantly expressed in intestinal epithelial cells of specific intestinal portions regulates expression of a negative signaling molecule to bacterial stimuli. These results are applicable to the evaluation system for food components which keep healthy symbiotic system in the intestine.
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| Free Research Field |
農学
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