2016 Fiscal Year Final Research Report
Comparative analysis of the interaction of Rad51 recombinase and tumor suppressor BRCA2 aimed at drug development
| Project/Area Number |
26450400
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIGURO Toshina (OONUMA Toshina) 岩手大学, 農学部, 准教授 (60452695)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | DNA損傷修復 / 乳腺腫瘍 / 放射線感受性 / BRCA2 / Rad51 |
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| Outline of Final Research Achievements |
Towards a better understanding of the molecular mechanisms of mammary tumor development in dogs, this study was focused on breast cancer tumor suppressor protein BRCA2 and its interacting recombinase Rad51 for an attempt to provide the basis of pure research leading to novel drug development and therapy for various mammals including dogs. Polymorphisms of canine BRCA2 affecting interaction with Rad51and reduced expression levels of BRCA2 in canine mammary tumors were found. Moreover, novel regulation mechanisms were shown for androgen receptor (AR) that is an BRCA2 interacting molecule.
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| Free Research Field |
動物疾病制御学
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