Study on the diagnostic significance of lipid peroxidation markers in obese dogs and cats

2016 Fiscal Year Final Research Report

• Project/Area Number: 26450435
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Nippon Veterinary and Life Science University
• Principal Investigator: Mori Nobuko 日本獣医生命科学大学, 獣医学部, 研究員 (10644536)
• Co-Investigator(Renkei-kenkyūsha): ARAI Toshiro 日本獣医生命科学大学, 獣医学部, 教授 (70184257)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肥満 / 犬 / 猫 / 脂質過酸化マーカー

Outline of Final Research Achievements

In order to properly evaluate the obesity of dogs and cats, it is necessary to evolve from the "quantitative indicator of accumulated lipids" to "qualitative index of accumulated lipids", focusing on lipid peroxidation marker I try to establish as a new marker. In dogs and cats, both paraoxokinase activity and allyl esterase activity of paraoxokinase (PON-1) could be measured. It was found that PON-1, an endogenous anti-lipid peroxidase, correlated with smaller particle size HDL cholesterol in normal dogs. Regarding oxidized LDL, there is a low relevance to dog and cat obesity, but some of obesity group showed several highs, and the possibility that it will be a useful marker showing symptoms of some disease has increased.It was also found that synthetic cholesterol is trend to be higher than in the absorption cholesterol in obesity cat's protein cholesterol.

Free Research Field

脂質代謝