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2016 Fiscal Year Final Research Report

Distribution and function of ADAMDEC-1 in the mouse placenta

Research Project

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Project/Area Number 26450445
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrative animal science
Research InstitutionYamaguchi University

Principal Investigator

Takeshi Kusakabe  山口大学, 共同獣医学部, 准教授 (20319536)

Research Collaborator KISO Yasuo  山口大学, 共同獣医学部, 教授
KANO Kiyoshi  山口大学, 共同獣医学部, 准教授
TAKESHITA Ai  和歌山医大, 医学部, 任期付研究員
Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsmetalloprotease / ADAM / uterine NK cells / placenta / vasodilation / angiogenesis
Outline of Final Research Achievements

Existence of a disintegrin and metalloprotease-like decysin (ADAMDEC-1) has been confirmed in the mouse placenta, but their reproductive function is unclear. We examined ADAMDEC-1 regarding the distribution and appearance patterns in the normal mouse placenta and effects on the placental capillaries and epithelial cells.This study showed the possibilities that ADAMDEC-1 is produced from the uterine NK cells in mouse placentas. Uterine NK cells seemed to release ADAMDEC-1 to maternal blood circulation and transit to fetal side of placenta. ADAMDEC-1 may help placental vasodilation and angiogenesis, and promote nutritional exchanges and fetal growth in placenta.

Free Research Field

細胞生物学

URL: 

Published: 2018-03-22  

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