2016 Fiscal Year Final Research Report
Distribution and function of ADAMDEC-1 in the mouse placenta
Project/Area Number |
26450445
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrative animal science
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Research Institution | Yamaguchi University |
Principal Investigator |
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Research Collaborator |
KISO Yasuo 山口大学, 共同獣医学部, 教授
KANO Kiyoshi 山口大学, 共同獣医学部, 准教授
TAKESHITA Ai 和歌山医大, 医学部, 任期付研究員
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | metalloprotease / ADAM / uterine NK cells / placenta / vasodilation / angiogenesis |
Outline of Final Research Achievements |
Existence of a disintegrin and metalloprotease-like decysin (ADAMDEC-1) has been confirmed in the mouse placenta, but their reproductive function is unclear. We examined ADAMDEC-1 regarding the distribution and appearance patterns in the normal mouse placenta and effects on the placental capillaries and epithelial cells.This study showed the possibilities that ADAMDEC-1 is produced from the uterine NK cells in mouse placentas. Uterine NK cells seemed to release ADAMDEC-1 to maternal blood circulation and transit to fetal side of placenta. ADAMDEC-1 may help placental vasodilation and angiogenesis, and promote nutritional exchanges and fetal growth in placenta.
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Free Research Field |
細胞生物学
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