2016 Fiscal Year Final Research Report
Synthetic study of habiterpenol
| Project/Area Number |
26460013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 全合成 |
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| Outline of Final Research Achievements |
Habiterpenol (1) was isolated from the fermentation broth of actinomycete Phytohabitans suffuscus 3787_5. Habiterpenol was found to abrogate bleomycin-induced G2 arrest in Jurkat cells. Due to its intriguing structural features and biological profile, total synthesis and structure-activity relationship study of this natural product were investigated. As a result, we successfully synthesized a key intermediate for the total synthesis.
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| Free Research Field |
有機合成
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