2016 Fiscal Year Final Research Report
Development of sustained release formulation by using crystal transition of active ingredient.
| Project/Area Number |
26460039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
Itai Shigeru 静岡県立大学, 薬学部, 教授 (80453059)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | sustained release / gastro-floating / Clarithromycin / polymorphism |
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| Outline of Final Research Achievements |
Clarithromycin(CAM) has 2 crystal forms at ambient temperature and meta-stable crystal(FormⅠ) transforms to stable crystal(FormⅡ) and hydrate(FormⅣ) immediately by contact with water. By using this property, we succeeded in development of highly --loaded CAM sustained release formulation with 0-order manner and gastro-floating formulation. FormⅡ can be obtained by dispersion in water-filtration-drying processes or heat treatment(150℃). Since these treatment lead to increase API cost, we tried and establish the transformation of FormⅠto FromⅡ during the manufacturing process of CAM formulation.
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| Free Research Field |
製剤設計、ＤＤＳ
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