Nanoparticle-based pulmonary drug delivery system to extend the nanomedicine

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460040
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: Tetsuya Ozeki 名古屋市立大学, 大学院薬学研究科, 教授 (60277259)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ナノコンポジット粒子 / 経肺投与 / ドラッグデリバリーシステム

Outline of Final Research Achievements

Various kinds of nanoparticle-based formulations, which are termed as nanomedicine, have been developing among researchers. However, most of nanomedicine is applied for intravenous injection and the administration route is a limitation for the principal use of nanomedicine. I have been developing various nanocomposite particles (microparticles containing functional nanoparticles) by using spray drying technology. The functional nanoparticles are expecting for not only lung-related diseases but also systemic diseases by passing through alveolar endothelial cells layer which is in the deepest lung tissue. I developed the composite particles containing ultra small gold nanoparticles or curcumin as poorly water soluble compound and then the nanocomposite particles were evaluated.

Free Research Field

製剤学、薬剤学、薬物送達学