2016 Fiscal Year Final Research Report
Physiological function of phosphatidylinositol 3,5-bisphosphate in oligodendrocytes
| Project/Area Number |
26460059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Akita University |
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Principal Investigator |
Takasuga Shunsuke 秋田大学, 医学(系)研究科(研究院), 助教 (90375262)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | イノシトールリン脂質 |
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| Outline of Final Research Achievements |
To elucidate physiological functions of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) in the central nervous system (CNS), we generated and analyzed CNS-specific type III phosphatidylinositol phosphate kinase (PIPKIII)-deficient mice. These mutant mice showed the severe demyelination in the brain, which suggest that PI(3,5)P2 regulates the myelination in CNS. Futhermore, the cell lineage-specific deletion of PIPKIII gene revealed that PIPKIII in oligodendrocytes but not neurons had essential roles for the myelination.
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| Free Research Field |
細胞生物学
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