2016 Fiscal Year Final Research Report
Mechanisms of remodeling of white adipocytes to brown-like adipocytes (browning) in human mesenchymal stem cells.
| Project/Area Number |
26460077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kinjo Gakuin University (2016)
Showa University (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脂質代謝 / 脂肪滴 |
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| Outline of Final Research Achievements |
Appearance of brown-like adipocytes within white adipose tissue depots (browning) is supposed to be a new target in anti-obesity therapy. The aim of this study was to assess the browning effect of various compounds such as fatty acids, polyphenols, FGF21 and irisin in human adipose-derived mesenchymal stem cells (hADSC). I found that irisin and FGF21 enhanced expression of BAT marker UCP1 and decreased levels of a lipid droplet-associated protein, perilipin1. In further, FGF21 induced levels of perilipin2, suggesting the remodeling from large lipid droplets to smaller droplets.
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| Free Research Field |
生物化学
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