2016 Fiscal Year Final Research Report
The role of microglia in ASDs.
| Project/Area Number |
26460094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Koyama Ryuta 東京大学, 大学院薬学系研究科(薬学部), 准教授 (90431890)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | マイクログリア / シナプス / 自閉症 |
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| Outline of Final Research Achievements |
Selective elimination of inappropriate synapses is fundamental to the refinement of neural circuits. Deficits in synapse elimination are suggested in autism spectrum disorders (ASDs). Here we investigated whether and how the deficits in synapse elimination in the hippocampus are involved in the pathogenesis of ASDs. We found that the deficits in microglia-mediated synapse elimination induce excess synaptic connections in the dentate gyrus-CA3 neural circuits in ASDs. Thus, we propose that the regulation of microglial activity is a key to suppress the development of ASDs.
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| Free Research Field |
神経科学
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