2016 Fiscal Year Final Research Report
Ameliorative effect of glutamate on Helicobacter pylori-related gastropathy
| Project/Area Number |
26460109
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Research Collaborator |
KANOU Yoshitaro
KITAI Kanako
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Helicobacter pylori / ヘリコバクターピロリ関連胃疾患 / グルタミン酸 |
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| Outline of Final Research Achievements |
Helicobacter pylori (H. pylori) is a major cause of chronic gastritis, gastroduodenal ulcers, and gastric cancer. Glutamate is known to be a major of umami substances and traditionally prefer in Asian countries. We found that the feeding of MSG-containing diet for 3 weeks, starting from 1 week before H. pylori inoculation, protected gastric mucosa against H. pylori-induced gastritis. MSG significantly prevented the colonization of H. pylori in the gastric mucosa, but did not have any effect on the growth of H. pylori on agar plate in vitro.
This action may be attributable to inhibition of inflammatory responses and colonization of H. pylori. MSG increases mucus production and TFF-1 expression in the gastric mucosa. Thus, it is assumed that preventive effect of MSG on the colonization of H. pylori in the gastric mucosa may be attributable to increase in mucus production and TFF-1 expression.
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| Free Research Field |
薬理学・薬物治療学
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