2016 Fiscal Year Final Research Report
Development of inhibitors based on the molecular structure and mechanism of substrate hydrolysis by metallo-beta-lactamases
| Project/Area Number |
26460147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kinjo Gakuin University (2015-2016)
Kumamoto University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 感染症 / ラクタマーゼ / 抗生物質 / Ｘ線結晶構造解析 / 阻害剤 / ラクタム剤 |
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| Outline of Final Research Achievements |
The emergence and rapid spread of carbapenem-resistant pathogens producing metallo-beta-lactamases such as IMP-1 and NDM-1 are of great concern in the clinical setting worldwide. There are no clinically available inhibitors for metallo-beta-lactamases at present. In order to develop the inhibitors for metallo-beta-lactamases, we synthesized seven novel compounds based on the X-crystal structure of metallo-beta-lactamase (IMP-1).
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| Free Research Field |
機器分析学
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