2016 Fiscal Year Final Research Report
Involvement of brain-specific induction of secretoglobin expression in methylmercury toxicity
| Project/Area Number |
26460170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science (2015-2016)
Tohoku University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | メチル水銀 / セクレトグロビン / 転写因子 |
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| Outline of Final Research Achievements |
In this study, we investigated the changes in gene expression levels in various tissues of methylmercury (MeHg)-treated mice and found that MeHg induced brain-specific expression of secretoglobin SCGB3A1. We also found that knockdown of SCGB3A1 increased the toxicity of MeHg in mouse neural progenitor C17.2 cells. Moreover, addition of recombinant SCGB3A1 to culture medium decreased the toxicity of MeHg in C17.2 cells, suggesting that extracellular SCGB3A1 plays a key role in the defense mechanism against toxicity of MeHg. Furthermore, NF-κB and TCF3, transcription factors, were involved in MeHg-induced SCGB3A1 expression.
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| Free Research Field |
分子毒性学
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