2016 Fiscal Year Final Research Report
Role of microRNA on the pharmacokinetics of calcineurin inhibitors after living liver transplantation
| Project/Area Number |
26460196
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Mie University |
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Principal Investigator |
OKUDA Masahiro 三重大学, 医学部附属病院, 教授 (70252426)
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| Research Collaborator |
HIRAMATSU Shunichi
HAMADA Yugo
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 臓器移植 / マイクロRNA / 免疫抑制薬 / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
Our study demonstrates that blood concentrations of tacrolimus (an immunosuppressant) are transiently elevated in patients with poor metabolizer of CYP3A5 in the early postoperative period of renal transplantation, and this is attributable to decreased CYP3A4 level via interleukin-6. On the other hand, microRNAs (miRNAs) affecting individual variations in the pharmacokinetics of immunosuppressant after organ transplantations was not identified in the present study. Further study is needed to achieve personalized pharmacotherapy with miRNAs.
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| Free Research Field |
医療薬学
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