2016 Fiscal Year Final Research Report
Biochemical properties of various organic ion transporters in central nervous system
| Project/Area Number |
26460210
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Ritsumeikan University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KATSURA Toshiya 立命館大学, 薬学部, 教授 (10283615)
|
|---|
| Research Collaborator |
Ganapathy Vadivel Texas Tech University, Health Sciences Center, 教授
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 有機イオントランスポーター / 初代培養神経細胞 / クエン酸回路 / エンケファリン輸送 |
|---|
| Outline of Final Research Achievements |
In this project, we characterized the expression and function of various organic solute transporters, such as amino acid transporter(s), dicarboxylate transporter(s), and opioide peptide transporters, in the central nervous system. After these experiments, functional regulation of these transporters was determined with neurochemical and biochemical techniques. We found that Na+-dependent enkephalin transporter, which is reported to be expressed in cultured neuronal cell line, is expressed functionally in mouse cerebrocortical neurons.
|
| Free Research Field |
薬物動態学
|
