Development of sustained-release formulations for cedar pollen-specific desensitization therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460226
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: Iwao Yasunori 静岡県立大学, 薬学部, 准教授 (30433022)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 減感作

Outline of Final Research Achievements

In this study, to develop a sustained-release formulation for cedar pollen-specific desensitization therapy, we determined the necessary amount or released rate of cryptomeria japonica pollen 1 (CryJ1), one of main allergen antigens of Japan cedar pollen, and we tried to prepare sustained-release formulation with long-term stability of CryJ1. As a result, the CryJ1 released rate to lead to immune tolerances was found to be 132 ng/day, and we succeeded in preparing PLAPEG9604H microspheres containing CryJ1 showing the sustained release at zero order manner. In addition, any structural changes of the cryj1 after long-term incubation were not found to influence the desensitization therapy.

Free Research Field

製剤学