2016 Fiscal Year Final Research Report
Development of hydrogel for treating the cencerous skin ulcer of progressive breast cancer.
Project/Area Number |
26460234
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Tokyo University of Science |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | ハイドロゲル / 電子線 / 進行性乳癌 / 皮膚潰瘍 / メトロニダゾール |
Outline of Final Research Achievements |
In order to development the hydrogel for treating the cencerous skin ulcer of progressive breast cancer.The aqueous solution of hydroxypropyl methylcellulose (HPMC) and poly acrylic acid (PAAc) was irradiated by electron beam in dose of 30 kGy and then HPMC/PAAc hydrogel was prepared. The concentration of HPMC and PAAc was 20% and 1-5%, respectively. To assess the effect of the addition effect of PAAc, gel fraction, gel swollen degree, gel strength test, drug release ratio and diffusion process were evaluatedmeasured. Gel fraction was higher increased within increase in response to the added amount of PAAc. In the basic conditions, HPMC/PAAc gel became higher swollen degree than HPMC alone. By adding PAAc, gel strength was changed. Drug release was confirmed and drug release ratio of every hydrogel was over than 70% in the basic condition. The diffusion process from all hydrogels showed a non-Fickian diffusion.
|
Free Research Field |
臨床製剤設計学
|