Comparison of in vivo antioxidant effect of polyphenols and development of novel formulations containing polyphenol

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460235
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Hoshi University
• Principal Investigator: Ikeuchi-Takahashi Yuri (高橋由里) 星薬科大学, 薬学部, 講師 (10339525)
• Co-Investigator(Renkei-kenkyūsha): KOBAYASHI Tsuneo 星薬科大学, 薬学部, 教授 (90339523) ; ONISHI Hiraku 星薬科大学, 薬学部, 教授 (00160565)
• Research Collaborator: TAGUCHI Kumiko ; ISHIHARA Chizuko ; NIGA Monami ; KATAYAMA Sota ; INOUE Mizuki ; KANGAWA Yoko ; MURAI Marina
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ポリフェノール / 過酸化脂質 / モリン / 固体脂質微粒子 / 生物学的利用率 / エマルション

Outline of Final Research Achievements

As a result of intraperitoneal administration of polyphenols to diabetic mice, a strong inhibitory effects on lipid peroxidation was observed in morin. Morin may be useful for relief from complaints related to lipid peroxidation, but because of its extremely low bioavailability, we developed solid lipid nanoparticles (SLN) for the purpose of improving bioavailability. SLN was prepared using hard fat as a base with ethylcellulose and low saponification-degree polyvinyl alcohol. As a result of oral administration of the SLN to mice, drug absorption was improved as compared with administration of morin bulk powder. Furthermore, we developed nanoemulsions containing morin. As a result of oral administration of the prepared nanoemulsion to mice, drug absorption was increased as compared with the administration of morin bulk powder.

Free Research Field

医療薬剤学