2016 Fiscal Year Final Research Report
Usefulness of the analysis of trace metals to predict adverse effects and understand their underlying mechanisms during platinum-based cancer chemotherapy
| Project/Area Number |
26460245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Osaka University of Pharmaceutical Sciences (2016)
Himeji Dokkyo University (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | プラチナ / 癌 |
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| Outline of Final Research Achievements |
The blood concentrations of platinum and trace metals including iron, copper, zinc, manganese and lead were determined in esophageal and lung cancer patients receiving cisplatin-based chemotherapy. The data for the patients who received a blood transfusion and iron tablet intake or had blood drawn while in non-fasting state were excluded from the analysis. The patients exhibited the increase in the plasma iron concentration within a week after the CDDP treatment, followed by a subsequent return to baseline level. This transient elevation may have been partly due to the anemia-associated lowering of hemoglobin value. The plasma zinc concentration was also increased on days 1-3 after the cisplatin treatment. The variation in the blood concentrations of iron and zinc showed a certain trend after the start of cisplatin-based chemotherapy, suggesting the usefulness of the analysis of trace metals in the body to understand the physiological responses to platinum-based cancer chemotherapy.
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| Free Research Field |
医療薬学
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