2016 Fiscal Year Final Research Report
The role of sex hormones in brain morphogenesis and sex differentiation
| Project/Area Number |
26460258
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | エストロゲン / 神経新生 / 大脳皮質 / 視床下部 / ビスフェノールA / ミクログリア / Steroidogenic factor-1 |
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| Outline of Final Research Achievements |
Estrogen receptors express in the neurons and microglia in the brain and regulate their activity. Neurosteroids are converted by aromatase and are involved in the development and maturation of the brain. In the study, we showed that SF-1, regulated the expression of estrogen-producing enzyme, were expressed in the neocortex and the brain derived estrogen controlled the proliferation, differentiation, and migration of neurons. In addition, toxicity evaluation by the prenatal exposure of estrogenic chemical substances resulted in the abnormalities in the hypothalamus construction, brain-inflammation, and increase of microglia. We suggest that estrogen signaling act on the neurons and microglia, and contribute to the proper development of brain.
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| Free Research Field |
解剖学
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