2016 Fiscal Year Final Research Report
Morphological and Molecular Cell Biological Study on an Intermediate filament protein, synemin.
| Project/Area Number |
26460268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | シネミン / 中間径フィラメント / 骨格筋 / 肝臓 / 線維化 |
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| Outline of Final Research Achievements |
To reveal the functions of intermediate filament protein, synemin, we studied skeletal muscles and liver. In skeletal muscles, the interaction between actinin 3 (ACTN3) and synemin was studied using immunoprecipitation and fluorescence microscope. Co-precipitation and co-localization of these proteins were found. Whereas mice lacking ACTN3 showed improvement of endurance, those lacking synemin showed its decline. We are now studying the mechanisms of the latter. In the liver, synemin is expressed in stellate cells. In experimental fibrosis models of the liver, synemin knockout mice showed the reduction of fibrosis compared with that of the wild type animals. This might lead to the prevention and/or treatment of fibrosis in human liver.
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| Free Research Field |
解剖学、細胞生物学
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