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2016 Fiscal Year Final Research Report

Fucosylation regulates reproduction system development.

Research Project

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Project/Area Number 26460269
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionChiba University

Principal Investigator

BABA Atsushi  千葉大学, 大学院医学研究院, 助教 (70405215)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords器官形成 / 糖鎖修飾 / フコシル化 / 発生・分化 / 細胞・組織 / 管腔様構造
Outline of Final Research Achievements

Developmental defect in the formation of tubular-like structure, is the relatively common desease in human, but its cause remains unknown. Celsr1 inactivation leads to anatomic block of tublar-like structure in reproductive system, and those phenotypes are mimicked in mice with inactivation of Lunatic fringe, which encodes an O-fucose-Nacetylglucosaminyltransferase. Two EGF-like motifs in Celsr1 are O-fucosylated and subject to Fringe modification. Mutation of O-fucosylation sites hampers decreases cell surface expression of the full length protein. Thus, post-transcriptional glycosylation regulates subcellular localization of Celsr1 protein, and participates in the formation of tubular-like structure.

Free Research Field

発生生物学

URL: 

Published: 2018-03-22  

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