Molecular mechanisms in the hormone-dependent differentiation of the mouse submandibular gland

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460270
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Kanazawa University
• Principal Investigator: ISEKI Shoichi 金沢大学, 医学系, 教授 (50167251)
• Co-Investigator(Renkei-kenkyūsha): WAKAYAMA TOMOHIKO 熊本大学, 大学院生命科学研究部, 教授 (70305100) ; YAMAMOTO MIYUKI 金沢大学, 医学系, 助教 (60139780) ; NAKATA HIROKI 金沢大学, 医学系, 講師 (80638304)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 細胞分化 / 組織形成 / 顎下腺 / 導管系 / アンドロゲン / 甲状腺ホルモン / 受容体

Outline of Final Research Achievements

Of the two kinds of sexual dimorphism in the mouse submandibular gland (SMG), the preferential increase of granular convoluted tubule (GCT) cells in males was lacking in androgen receptor (AR)-deficient mice (ARKO) and, thus, proved to be dependent on AR, whereas the administration of thyroid hormone (T4) to ARKO caused increase of GCT cells independent of AR. On the other hand, the preferential decrease of granular intercalated duct (GID) cells in males was lacking in ARKO, and administration of T4 caused no decrease of GID cells, suggesting that the two kinds of sexual dimorphism have different hormone dependency. Furthermore, the gene expression profile of the normal and ARKO SMG identified numbers of new GCT-specific gene products.

Free Research Field

医歯薬学