Effect of regional increase in ROS on arrhythmia susceptibility in the myocardium with nonuniform contraction

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460288
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Tohoku University
• Principal Investigator: Miura Masahito 東北大学, 医学系研究科, 准教授 (30302110)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 活性酸素 / 細胞内カルシウム / 不整脈

Outline of Final Research Achievements

In diseased hearts, impaired muscle with reduced contractile strength is distributed throughout the hearts and is stretched by contractions of more viable neighboring muscle during the contraction phase. In addition, it has been reported that muscle stretch transiently increases the production of reactive oxygen species (ROS). The present study demonstrates that, focusing on the ROS production, the passive stretch of the impaired muscle regionally increases the ROS production, accelerate calcium waves arising from the impaired region, and causes triggered arrhythmias.

Free Research Field

臨床生理検査学