2016 Fiscal Year Final Research Report
The physiological role of TASK channel in adrenaline secretion
| Project/Area Number |
26460306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | TASKチャネル |
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| Outline of Final Research Achievements |
I investigated the function and physiological role of TASK1 channels in endocrine cells. Pharmacological and molecular biological analyses showed that TASK1 channels are regulated by the clathrin-dependent endocytosis in NGF- and muscarine-stimulated adrenal medullary and PC12 cells. Additionally, it showed that the molecular mechanisms regulating channel endocytosis differ between NGF-induced endocytosis and muscarine-induced endocytosis. The AM cells prepared from TASK1 KO mice indicated the decrease of pH sensitivity and adrenaline secretion, suggesting TASK1 channels play an important role in a sensor of acidosis and adrenaline secretion in AM cells.
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| Free Research Field |
細胞生理学
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