Research for heart protection during cancer chemotherapy via regulating cardiac autophagy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460350
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Tenri Health Care University
• Principal Investigator: Iwai-Kanai Eri 天理医療大学, 医療学部, 教授 (20372584)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心不全 / 抗がん剤 / ミトコンドリア / オートファジー / エネルギー代謝

Outline of Final Research Achievements

Using GFP-LC3 transgenic mice or neonatal rat cardiac myocytes, we demonstrated that Curcumine inhibited both cardiac apoptosis and cardiac dysfunction induced-by Doxorubicin. Curcumine significantly improved mortality in mice with anti-cancer chemotherapy (Clin Exp Card.2015). Also, we showed that cardiac autophagy was activated and acted as cardioprotection by through mTOR-independent Akt signal in the heart failure with sympathicotonia (Biochem Biophys Res Commun.2014). In addition, defect in metabolism of lipid and amino acid was revealed to be a key for the progress of heart failure (Am J Physiol Heart Circ Physio.2016, Sci Rep 2017). These findings indicated that regulating energy metabolism and autophagy would be a novel therapeutic target for heart failure with cancer chemotherapy.

Free Research Field

循環器内科学