2016 Fiscal Year Final Research Report
Elucidation of novel function of biologic defense molecule collectin CL-K1
| Project/Area Number |
26460353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | コレクチン / 発生・分化 / 糖鎖 / 自然免疫 / 補体 |
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| Outline of Final Research Achievements |
Collectin CL-K1 was a secreted protein and was known as an innate immune molecule involved in elimination of microbes, but CL-K1 was involved in development and growth, so we attempted to elucidate its role and mechanism. Regarding the developmental process, phenotypic abnormalities could be found in CL-K1 KO mice from the morphology from embryogenesis to birth after implantation and from blood biochemical data. Phenotypic analysis in adults revealed abnormal tissue in H-E staining of each tissue specimen, further found abnormality in bone formation by using X-ray and CT apparatus, and clarified renal function abnormality by hematological analysis and urinalysis.
By clarifying completely new functions other than biological defense of collectins, "dual function of biological defense proteins" could be proved in animal models.
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| Free Research Field |
免疫学
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