2016 Fiscal Year Final Research Report
Elucidation of the mechanisms of organ size determination
| Project/Area Number |
26460358
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 臓器サイズ / 胚盤胞補完法 / 異種動物 |
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| Outline of Final Research Achievements |
In order to understand the mechanisms of determination of the size of body or the organ, - specifically, whether that is controlled by intrinsic or extrinsic cues, we performed interspecies blastocyst complementation. As a result, the size of mouse pancreas generated in rat was rat size (about ten times larger than mouse pancreas). This result indicate that the extrinsic signal as well as intrinsic signal is important for the organ size determination.
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| Free Research Field |
再生医学
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