2017 Fiscal Year Final Research Report
Regulation of glucose metabolism pathway by nucleoredoxin
| Project/Area Number |
26460364
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Funato Yosuke 大阪大学, 微生物病研究所, 助教 (60505775)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | nucleoredoxin / 代謝 / グルコース |
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| Outline of Final Research Achievements |
Nucleoredoxin (NRX) is a Thioredoxin family protein. We searched for novel binding protein for NRX, and identified glycolysis enzyme PFK1 as a major one.
To clarify the regulation of glycolytic pathway by NRX, we performed metabolome analyses with wild type and NRX-deficient MEF cells. We found that the metabolites produced downstream of PFK1, such as lactate, decreased, and the products of pentose phosphate pathway, which diverges at the upstream of PFK1, increased. Thus, these results strengthen the notion that NRX regulates the balance between glycolytic pathway and the pentose phosphate pathway through PFK1.
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| Free Research Field |
細胞生物学
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