2016 Fiscal Year Final Research Report
Elucidation of mucosal repair mechanism mediated by interleukin 11 in inflammatory bowel disease
| Project/Area Number |
26460397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | レポーターマウス / 大腸炎 / IL-11 / 大腸がん / IL-6サイトカインファミリー / 粘膜 / サイトカイン / 修復 |
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| Outline of Final Research Achievements |
Interleukin (IL)-11 is a member of IL-6 family of cytokines that activates signal transducer and activator of transcription 3. Accumulating studies have shown that IL-11 is highly expressed in inflammatory bowl diseases and colorectal cancers in human and mice. However, it remains unclear whether IL-11 plays a crucial role in maintaining tissue homeostasis of the intestine. In this study, using dextran sodium sulfate (DSS)-induced colitis in mice as a model, we found that IL-11 was produced by non-bone marrow-derived cells that were localized in injured intestinal tissues. Moreover, IL-11 primarily acted on intestinal epithelial cells and protected injury of intestinal epithelial cells, thereby attenuating DSS-induced colitis. These findings indicate that IL-11 plays a crucial for maintaining intestinal homeostasis.
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| Free Research Field |
病態生化学
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