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2016 Fiscal Year Final Research Report

Evaluation of potential clinical application of tight junction proteins in cervical adenocarcinoma

Research Project

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Project/Area Number 26460421
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionSapporo Medical University

Principal Investigator

Takasawa Akira  札幌医科大学, 医学部, 助教 (00593021)

Co-Investigator(Renkei-kenkyūsha) SAWADA NORIMASA  札幌医科大学, 医学部, 教授 (30154149)
TANAKA SATOSHI  札幌医科大学, 医学部, 講師 (30374250)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords子宮頚部 / 子宮頚部腺癌 / タイト結合 / 治療・診断マーカー
Outline of Final Research Achievements

We exam the expression of tight junction proteins in uterine cervical adenocarcinoma specimens. We found that expression of Claudin-1 and JAM-A was significantly higher in cervical adenocarcinoma than in non-neoplastic glands. In adenocarcinoma, localization of Claudin-1 and JAM-A was extended throughout the whole cell membranes, whereas they were predominantly expressed at the most apical cell-cell junction in non-neoplastic glands. Immunoreactivities and localization of Claudin-1 and JAM-A successfully distinguished neoplasms from non-neoplastic cervical glands with high specificity and high sensitivity. In cervical adenocarcinoma cell lines, gene knockout of Claudin-1 suppressed tumorigenicity, invasive capacity and tumor-initiation of cancer cells. Expression of Claudin-1 was mediated by ERK signaling. Targeting of Claudin-1 may be effective for cervical adenocarcinoma diagnosis and therapy.

Free Research Field

医歯薬学

URL: 

Published: 2018-03-22  

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