2016 Fiscal Year Final Research Report
Study of tumor microenvironment in pancreatic cancer and their precursor lesions.
| Project/Area Number |
26460425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 膵癌 / 前癌病変 / 微小環境 |
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| Outline of Final Research Achievements |
We studied tumor microenvironment in pancreatic cancer and their precursor lesions. First, we found that mast cell infiltration was significantly increased in the periductal stroma of one of the precursors of pancreatic cancer (IPMNs). Mast cells may be related to tumor progression during non-invasive stage of them. Second, MUC13 expression was more frequently observed in higher grade of IPMN, and was associated with poor prognosis of the patients. Third, using immunohistochemical method, we indicated that atypical flat lesion (AFL), recently described as a precursor of pancreatic cancer mainly in mice, was a possible precursor in human, too. Fourth, since there has been no consensus on the method and criteria for evaluation of lymph vessel invasions (LVIs), we analyzed on the whole of the largest cut sections of the pancreatic cancer specimens and determined appropriate criteria of LVIs. Furthermore, we found distribution of LVIs has a tendency to exist near the duodenum or bile duct.
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| Free Research Field |
病理学、
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