2016 Fiscal Year Final Research Report
Virus antigen specific CTL in HTLV-1 and EBV associated lymphoma
| Project/Area Number |
26460446
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ATLL / HTLV1 / TAX / FoxP3 / T reg / CTL / HLA A24 |
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| Outline of Final Research Achievements |
HTLV-1 Tax has been reported to play an important role in ATLL and to be a target of HTLV-1-specific CTL. However, it is not clear how Tax-specific CTL behave in lymph nodes. We analyzed TAX-specific CTL. Furthermore, ATLL tumor cells are known to be positive for Foxp3 and to have regulatory T-cell (T-reg) like function. We also investigated the relationship between T-reg function and TAX-specific CTL. Immunohistochemical staining of tax protein showed positive lymphoma cells ranged 5% to 80%, and HLA-A24 showed positive cells ranged 1% to 95%. FoxP3 for T-reg were expressed in 0% to 90%. Some of cases showed Tax-specific CTL (HLA-A24-restricted) positive cells and there were inverse correlation between Tax-specific CTL and Foxp3. However, TAX and HLA A24 expression were not associated with CTL and FoxP3. The study showed the possibility that ATLL cells, which expressed TAX of CTL target, evade from CTL-mediated immune control by expression of FoxP3, as regulatory T cell function.
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| Free Research Field |
病理
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