2016 Fiscal Year Final Research Report
Elucidation the mechanism of epithelial differentiation induced by claudin, tight junction protein.
| Project/Area Number |
26460475
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Tomikawa Naoki 福島県立医科大学, 医学部, 講師 (80468587)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 上皮分化 / 幹細胞 / 細胞間接着分子 |
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| Outline of Final Research Achievements |
In this study, we clarified that claudin-6, cell-cell adhesion protein, induces the differentiation from stem cells to epithelial cells using mouse embryonic stem cell line and mouse embryonic stem cells. Moreover, we identified the mechanism that claudin-6 activated Src and Blk, a intracellular signaling molecule by directly interaction and subsequently activated PI3K、Akt and mToR. Claudin-6-induced signaling cascade arrived in retinoid receptor, a nuclear receptor, and regulate the expression of the epithelial differentiation-related molecules.
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| Free Research Field |
細胞生物学
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