2016 Fiscal Year Final Research Report
Analysis of pathogenic mechanism in novel NASH model mice
| Project/Area Number |
26460485
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Warabi Eiji 筑波大学, 医学医療系, 講師 (70396612)
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | NASH |
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| Outline of Final Research Achievements |
The aim of this study is to elucidate the pathological mechanism of NASH in p62:Nrf2 double knockout mice that were recently developed by our group and found that they showes a very similar phenotype to human NASH. It is suggested that in DKO mice, intestinal epithelial permeability is accelerated, resulting in high endotoxinemia, causing inflammation in the liver. It is considered that these defects are main reasons for NASH onset.
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| Free Research Field |
分子生物学
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