2016 Fiscal Year Final Research Report
A New nanoparticle glycogen for development of vaccine against malaria
| Project/Area Number |
26460511
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Kagoshima University |
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Principal Investigator |
Miyata Takeshi 鹿児島大学, 農水産獣医学域農学系, 准教授 (20448591)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | マラリア / ワクチン / 伝搬阻止 / 三日熱マラリア原虫 |
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| Outline of Final Research Achievements |
We have developed a new technology to enhance immune responses by generating complex which composed DNA-binding protein fused vaccine antigen, DNA and nano-particle glycogen (NPG). In this system, NPG was used as scaffold material, DNA was used as crosslinker material for vaccine antigen and NPG. New tricomponent vaccine complex (DBP-Vaccine/DNA/NPG) function was evaluated using an ookinete surface protein of Plasmodium vivax, Pvs25. The tricomplex immunized mice were conferred a high immune response compared to Pvs25 alone or DBP-Pvs25/DNA complex immunized groups. This system may be a promising approach for development of subunit vaccines against malaria.
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| Free Research Field |
医歯薬学
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