2016 Fiscal Year Final Research Report
Molecular mechanisms underlying exogenous sterol uptake in pathogenic fungus
| Project/Area Number |
26460541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Ryukoku University (2015-2016)
National Institute of Infectious Diseases (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | カンジダ / ABCトランスポーター |
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| Outline of Final Research Achievements |
The pathogenic fungus Candida glabrata, a commensal yeast that is resident in the human gastrointestinal tract, causes disseminated infection in immune-compromized host. Although C. glabrata has been thought to take up extracellular sterols in the host body, its physiological significance and molecular mechanisms have not been elucidated. From the analysis of the gene-disrupted C. glabrata strain, we demonstrated that the sterol transporter Aus1p and the cell wall mannoprotein Tir3p were essential for sterol uptake, and the expression levels of AUS1 and TIR3 were up-regulated under the iron deficiency condition similar to blood stream infection.
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| Free Research Field |
微生物学
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