2016 Fiscal Year Final Research Report
Will Saffold virus infection be a trigger of autoimmune disease (especially type 1 diabetes)?
| Project/Area Number |
26460561
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Saffoldウイルス / 糖尿病 / 膵炎 / ウイルス蛋白 / 感染受容体 |
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| Outline of Final Research Achievements |
The epidemiological study on type I diabetes mellitus and acute pancreatitis strongly suggests the pathogenicity of SAFV to pancreas. However, we could not establish the relationship between the diseases and SAFV infection since the number of cases was not enough. The study of the receptor for SAFV infection is also ongoing. On the other hand, unexpected findings were obtained in this study. We found that the PEST sequence in SAFV VP1 is a responsible element for its instability. The degradation of SAFV VP1 was suppressed with the co-expression of other capsid proteins, suggesting that the PEST sequence is masked and VP1 is stabilized during capsid formation. In addition, unknown viral protein was found, presumably translated from a non-AUG codon in an IRES dependent manner.
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| Free Research Field |
ウイルス学
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