2016 Fiscal Year Final Research Report
Study on local regulation of gene expression of female reproductive-specific IFN
| Project/Area Number |
26460567
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Hirosaki University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 自然免疫 / 産婦人科 / 感染症 / IFN |
|---|
| Outline of Final Research Achievements |
IFN-εis unique reproductive-specific type I IFN. We have shown that importin 9 (IPO9) regulate IFN-ε. In this study, we focused on local regulation of gene expression of IFN-ε. Analysis for 5’ untranslated region of IFN-εmRNA showed that IPO9 unaffected mRNA stability of IFN-ε. In addition we found molecules that can interact with IPO9.
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| Free Research Field |
免疫学
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