Linkage of sleep apnea syndrome and diabetic nephropathy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460645
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: University of Fukui
• Principal Investigator: Takahashi Naoki 福井大学, 学術研究院医学系部門(附属病院部), 助教 (30377460)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 睡眠時無呼吸症候群 / 糖尿病性腎症 / ポドサイト / 低酸素

Outline of Final Research Achievements

The purpose of this study was elucidation of molecular mechanisms between sleep apnea syndrome (SAS) and diabetic nephropathy progression based on urinary podocytes and urinary microRNA of podocytes using BTBR ob/ob mice under intermittent hypoxia environment. However, the kidney lesion of BTBR ob/ob mice was not severer than our expectation and obviously recognized sex differences (♂>♀). Many male BTBR ob/ob mice were necessary to accomplish this experiment at the same time. But it was the most difficult. Although we obtained several male BTBR ob/ob mice and bred under intermittent hypoxic environment, the death rate was increased more than our expectation. Finally, it was not analyzed enough about BTBR ob/ob mice in chronic intermittent hypoxic condition.

Free Research Field

検査医学