2016 Fiscal Year Final Research Report
Elucidation of the mechanisms of the association between resistin and type 1 diabetes. – The establishment of novel laboratory procedure for prediction of insulin dependent diabetes mellitus -
| Project/Area Number |
26460652
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 1型糖尿病 / レジスチン / 1型糖尿病関連因子 |
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| Outline of Final Research Achievements |
First, we isolated total RNA from monocyte derived from subjects with high serum resistin level and low resistin levels. And then we compared the difference of gene expression by DNA array, RNA-seq and bioinformatics approach. It revealed that gene expression of two factors related to type1 diabetes were increased in the subjects with high resistin group. Furthermore, we found that serum resistin level is associated with gene expression and protein level of these two factorsrelated to type1 diabetes. Our results suggest that resistin level is associated with type1 diabetes related two factors, and it may induce impaired insulin secretion independent of GAD antibody.
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| Free Research Field |
医学
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