Exploration of HDL functional measurement as a novel biomarker for atherosclerosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460664
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Fukuoka University
• Principal Investigator: Bo Zhang 福岡大学, 医学部, 准教授 (80352251)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 高比重リポ蛋白 / 動脈硬化病変 / 血管内超音波 / 多変量データ解析

Outline of Final Research Achievements

This study examined the association between the HDL functionality and coronary atherosclerosis, as assessed by intravascular ultrasound (IVUS), in patients with stable coronary artery disease (SCAD) who had type 2 diabetes mellitus (T2DM), using multivariate data analysis (MVDA). HDL efflux capacity and HDL inflammatory index were used as functional measurement of HDL. Coronary plaque volume/area and composition of target lesion were measured using gray-scale IVUS and IB-IVUS. OPLS (orthogonal partial squares projections of latent structures) model indicated that HDL inflammatory index was associated with both the fibrosis content and the thickness of fibrous cap of coronary plaque, while HDL efflux capacity and apolipoprotein A-1, the major protein of HDL, was mainly associated with the fibrosis content of coronary plaque. This finding suggests that HDL function is related to the vulnerability of coronary plaque in SCAD patients with T2DM..

Free Research Field

脂質異常症，動脈硬化