2016 Fiscal Year Final Research Report
Diagnostic markers of glandular lesion and their precursor lesions of uterine cervix
| Project/Area Number |
26460673
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
OTA Hiroyoshi 信州大学, 学術研究院保健学系, 教授 (50273107)
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| Research Collaborator |
ASAKA Shiho
KUBOTA Seiko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 胃型腺癌 / 子宮頸部腺系病変 |
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| Outline of Final Research Achievements |
In lobular endocervical glandular hyperplasia (LEGH), adenocarcinoma in situ and invasive adenocarcinoma, TFF1 was expressed 100/75/82.5%, TFF2 was expressed 100/37.5/44.8% and GlcNAcα→R recognized by antibody HIK1083 was expressed 100/37.5/44.8%. TFF2 expressed the same localizations with those of GlcNAcα→R. The secretions within the glandular lumens reacted positively for TFF2. TFF2 levels in cervical discharge measured using ELISA were higher in patients with higher scores of latex agglutination test using HIK1083 antibody. Screening of TFFs in cervical discharge may facilitate detection of cervical glandular lesion.
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| Free Research Field |
病理学
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