2016 Fiscal Year Final Research Report
Discovery of cytokine contributing to physiological sensory sensitivity adjustment and elucidation of controlling mechanism of pain
| Project/Area Number |
26460699
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Saga University |
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Principal Investigator |
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| Research Collaborator |
SASAGURI Tomoko
MURATA Yuzo
IIZASA Sayaka
ISHIKAWA Asako
HARA Hiromitsu
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ＩＬ-27 / 痛覚過敏 / 感覚感度の調節 |
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| Outline of Final Research Achievements |
We show evidences that constitutive existence of IL-27 controls threshold of sensation that induce aversive behavior in physiological and pathological conditions. Mice lacking IL-27 signaling possessed chronic pain-like hypersensitivity without any treatments. Reconstitution of IL-27 in these mice reversed hypersensitive threshold of aversive behavior. Furthermore, these mice showed additional hypersensitivity when subjected to commonly used chronic pain models suggesting that the mechanism of hypersensitivity induced by ablation of IL-27 signaling was different from ones underlying known chronic pain models.
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| Free Research Field |
疼痛学
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