Application of blood/tissue boron analysis for in-hospital BNCT

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460718
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Ibaraki Prefectural University of Health Science (2016); University of Tsukuba (2014-2015)
• Principal Investigator: NAKAI KEI 茨城県立医療大学, 公私立大学の部局等, 准教授 (50436284)
• Co-Investigator(Renkei-kenkyūsha): SATO Takahiro 国立研究開発法人 量子化学技術研究開発機構, 高崎量子応用研究所・放射線高度利用施設部, 研究副主幹 (10370404) ; KOKA Masashi 国立研究開発法人 量子化学技術研究開発機構, 高崎量子応用研究所・放射線高度利用施設部, 技術開発協力員 ; YAMADA Naoto 国立研究開発法人 量子化学技術研究開発機構, 高崎量子応用研究所・放射線高度利用施設部, 技術開発協力員
• Research Collaborator: KURITA Tadashi ; ENDO Keita ; ENDO Kiyoshi ; MIYAKAWA Makiko ; MATSUSHITA Akira ; OKAMOTO Emiko ; KITAMURA Akane ; YAMAMOTO Tetsuya ; YAMAMOTO Yohei
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: BNCT / ホウ素中性子捕捉療法 / PIXE / PIGE

Outline of Final Research Achievements

Micro-PIXE/PIGE analysis was performed at Takasaki Ion Accelerators for Advanced Radiation Application. The liquid boron containing samples were measured and were able to quantitation within 10-15min. The cellular samples that attached on thin polycarbonate membranes were freeze-dried. Elements (Potassium, Phosphate, Boron) distribution images were analysed. After 800ug/mL Boron containing medium exposure, The cell image analysis showed the coresident of boron and cells. less than 300 ug/mL Boron containing medium, boron could not distinguish between boron and background. Higher sensitivity or higher resolution would be needed.

Free Research Field

脳神経外科　リハビリテーション