FGF23-Klotho is associated with the progression of a disease of aging matter lesions

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460751
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: OZAKI ETSUKO 京都府立医科大学, 医学(系)研究科(研究院), 助教 (00438219)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: FGF23 / BAP / UCAR / non-CKD

Outline of Final Research Achievements

We investigated whether Phosphate (P) load into circulation might cause renal damage in non-CKD women. This cross-sectional study included 1,094 non-CKD Japanese women. Fibroblast growth factors (FGF)-23 as the parameters for P load, bone alkaline phosphatase (BAP) as the bone metabolic marker, and urinary albumin-to-creatinine ratio (UACR) as an early marker for renal damage were measured.
Postmenopausal women exhibited significantly higher levels of serum P, FGF-23, BAP, and UACR and significantly lower eGFR than in premenopausal women. In premenopausal women, although serum FGF-23 failed to correlate with log UACR, multiple regression analysis elucidate FGF-23 to associate significantly in a positive manner with log UACR. In postmenopausal women, multiple regression analysis confirmed the significant and independent association between serum BAP and log UACR.

Free Research Field

栄養疫学