Lipid management based on gender difference for prevention of cardiovascular disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460789
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Takegami Misa 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (50456860)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脂質管理 / 循環器疾患 / コホート研究 / 地域住民

Outline of Final Research Achievements

Dyslipidemia is an established risk factor for cardiovascular disease, but the existence of several lipid measures for preventive cardiovascular disease may make interpretation difficult for residents. In addition, changes in serum lipid levels with aging differ greatly between men and women, and thus efficient and appropriate lipid management based on sex is necessary. In this study, we examined the relationship between lipid measures and cardiovascular disease, stratified by sex group. Low-density lipoprotein (LDL) cholesterol, total cholesterol, and ratio of LDL to high-density lipoprotein cholesterol was associated with ischemic heart disease onset in men, but no association was found in women. Low LDL cholesterol is a risk factor for cerebral hemorrhage in women; this suggests the need for further studies that explore the optimal cut-off point for lipid measures, including other factors, such as biomarkers and lifestyle, in lipid management for women.

Free Research Field

疫学